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Check prices for these dates

Tonight
8 May - 9 May
Tomorrow
9 May - 10 May
This weekend
8 May - 10 May
Next weekend
15 May - 17 May

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,009 reviews)
"Nice place to stay"
United States
Lance
The price is AU$176
includes taxes & fees
4 June - 5 June
Drury Inn & Suites Sikeston, MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (555 reviews)
"Perfect nights stay!! "
United States
Amanda
The price is AU$165
includes taxes & fees
7 June - 8 June
Hampton Inn Sikeston
Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (763 reviews)
"The staff was great very helpful and friendly "
United States
Javier
The price is AU$76
includes taxes & fees
7 June - 8 June
New Orleans Inn Portageville
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (570 reviews)
"Very clean nice staff and well run "
United States
zach
The price is AU$98
includes taxes & fees
10 May - 11 May
Country Hearth Inn & Suites Union City
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"All very just okay "
United States
Sherry
The price is AU$115
includes taxes & fees
11 May - 12 May
The Riverstone Hotel Charleston-Sikeston
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (772 reviews)
"Breakfast was adequate room was clean."
United States
Daniel
The price is AU$89
includes taxes & fees
24 May - 25 May
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (631 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is AU$94
includes taxes & fees
1 June - 2 June
Super 8 by Wyndham Charleston/Sikeston East MO
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,002 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is AU$128
includes taxes & fees
20 May - 21 May
Best Western Plus Sikeston I-55
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (462 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is AU$158
includes taxes & fees
7 June - 8 June
Holiday Inn Express & Suites Sikeston Southwest by IHG
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (74 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
The price is AU$172
includes taxes & fees
4 June - 5 June
Fairfield Inn & Suites by Marriott Sikeston
Room, 1 Queen Bed, Non Smoking

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (62 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is AU$113
includes taxes & fees
25 May - 26 May
Super 8 By Wyndham Marston
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (385 reviews)
"Great stay. "
United States
Paul
The price is AU$139
includes taxes & fees
24 May - 25 May
Sleep Inn at Discovery Park of America
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,002 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is AU$97
includes taxes & fees
11 May - 12 May
Days Inn and Suites by Wyndham Sikeston
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (391 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is AU$94
includes taxes & fees
19 May - 20 May
Hospitality House Union City I 69 / US 51
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (509 reviews)
"Bathroom walls were dirty and bathroom ceiling had mold on it"
United States
Emily
The price is AU$114
includes taxes & fees
17 May - 18 May
Quality Inn Union City US 51
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is AU$106
includes taxes & fees
10 May - 11 May
Eagle Inn Charleston
Room, 1 King Bed, Accessible, Non Smoking

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (622 reviews)
"Cheap room not bad for the price. Would stay again if I was in the area. "
United States
Jenny
The price is AU$99
includes taxes & fees
15 May - 16 May
Super 8 by Wyndham Sikeston/Miner Area
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (182 reviews)
"Spotless , friendly staff."
United States
Gail
The price is AU$182
includes taxes & fees
24 May - 25 May
Hampton Inn Union City
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (325 reviews)
"Great hotel. Well worth it"
United States
Shannon
The price is AU$190
includes taxes & fees
17 May - 18 May
Holiday Inn Express & Suites Union City by IHG
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (285 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is AU$109
includes taxes & fees
5 June - 6 June
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"Staff is great rooms clean no bugs and bed was comfortable "
James 1-night trip
Posted 7 hours ago
Super 8 by Wyndham Sikeston/Miner Area

More cheap accommodation in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is AU$89 per night from 24 May to 25 May
AU$89
24 May - 25 May
includes taxes & fees
8.4/10 Very Good! (772 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters: This holiday home rental outside of East Prairie is located on a lake, and has a fireplace, a patio and a BBQ to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Sikeston Depot Museum and River Ridge Winery in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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