East Prairie Hotel & Accommodation Deals 2026 from AU$88 - Compare prices by date

A tree-lined landscape with a river and fields.

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Pool

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Waterpark

Pet friendly

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Our top choices for East Prairie hotels

Desk, blackout curtains, iron/ironing board, free cots/infant beds

1. Drury Inn & Suites Sikeston, MO

Sikeston

AU$181

includes taxes & fees

14 Aug - 15 Aug

2. Hampton Inn Sikeston

Sikeston

Brandi

AU$158

includes taxes & fees

23 Aug - 24 Aug

Indoor pool, open 8 AM to 11 PM, pool loungers

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

michael

AU$155

includes taxes & fees

23 Aug - 24 Aug

Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed)

4. Best Western Plus Sikeston I-55

Sikeston

Kevin

AU$154

includes taxes & fees

16 Aug - 17 Aug

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Dwain

AU$176

includes taxes & fees

23 Aug - 24 Aug

Desk, free WiFi, alarm clocks, bed sheets

6. Comfort Inn & Suites Sikeston I-55

Sikeston

Starlette

AU$154

includes taxes & fees

30 Aug - 31 Aug

Desk, laptop workspace, blackout curtains

7. The Riverstone Hotel Charleston-Sikeston

Charleston

Bobby

AU$104

includes taxes & fees

7 Sept - 8 Sept

8. TownePlace Suites by Marriott Sikeston

Sikeston

Jason

AU$175

includes taxes & fees

16 Aug - 17 Aug

Desk, blackout curtains, iron/ironing board (on request), free WiFi

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

AU$109

includes taxes & fees

12 Aug - 13 Aug

Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

10. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

France

AU$88

includes taxes & fees

8 Sept - 9 Sept

1 bedroom, desk, laptop workspace, blackout curtains

11. Days Inn and Suites by Wyndham Sikeston

Sikeston

"The hotel looked very good from the outside. And when you first went into the lobby was very nice. But the rooms were very basic. They was absolutely no pictures hung from the walls. The kitchen area just had a small refrigerator and a microwave setting on top of it. I had to ask for a coffee maker, and it was a single cup coffee maker. The free breakfast was very minimal. But at least everything was clean."

Robert S

AU$104

includes taxes & fees

9 Sept - 10 Sept

12. Super 8 By Wyndham Marston

Marston

Temera

AU$119

includes taxes & fees

11 Aug - 12 Aug

Room, 1 King Bed, Non Smoking | View from room

Room, 1 King Bed, Non Smoking | Bathroom

Desk, iron/ironing board, free WiFi, alarm clocks

13. Eagle Inn Charleston

Charleston

Jackson

AU$109

includes taxes & fees

11 Aug - 12 Aug

Iron/ironing board (on request), free WiFi, bed sheets

14. Country Yard Inn and Suite

Sikeston

William

AU$97

includes taxes & fees

1 Sept - 2 Sept

Standard Room, 2 Double Beds, Non Smoking

15. Quality Inn Cairo I-57

Cairo

Sharon

AU$113

includes taxes & fees

16 Aug - 17 Aug

16. Sleep Inn at Discovery Park of America

Union City

Ben

AU$133

includes taxes & fees

30 Aug - 31 Aug

17. Travel Inn Marston I-55 by Hotel O

Marston

Frank

AU$98

includes taxes & fees

11 Aug - 12 Aug

Standard Room, 1 King Bed, Accessible, Non Smoking

18. Country Hearth Inn & Suites Union City

Union City

Jade

AU$95

includes taxes & fees

24 Aug - 25 Aug

19. Quality Inn Union City US 51

Union City

Lisa

AU$112

includes taxes & fees

29 Aug - 30 Aug

Room, 1 King Bed, Accessible, Non Smoking

20. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

James

AU$106

includes taxes & fees

16 Aug - 17 Aug

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

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Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Sleep Inn at Discovery Park of America

8/10 Good

"Room was very clean. Property in general was very clean."

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Nice staff. Very accommodating."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"the room was clean and had everything we needed for a 1 night stay!"

Quality Inn Union City US 51

10/10 Excellent

"Property was almost out of the city."

Best Western Plus Sikeston I-55

10/10 Excellent

"Front desk was super helpful"

Holiday Inn Express & Suites Sikeston Southwest by IHG

8/10 Good

"Staff was super nice, giving us more than plenty towels upon request as I mentioned reviews found the suite was only equipped with towels for 2. A convenient and cozy place to stay for a night. Adequate hot breakfast. Gym is small with only bikes, treadmills and weights. The A/C on the wall in the gym was dripping hard. Our room was near the elevator and the wall seemed to be as thin as cardboard as I could hear every sound throughout the night. Bed mattress too soft for me."

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"Was a very clean, quiet place to stay. My only complaint was the breakfast was disappointing. They only offered cereal or waffles. Being diabetic I couldn't have either 😥. Yogurt, fruit, eggs/bacon/sausage would be good options. The staff was very nice and helpful."

Comfort Inn & Suites Sikeston I-55

8/10 Good

"Convenient to the interstate. Close to food selection. Nice breakfast bar. Overall well maintained."

Duck Hunting, Fishing or Relaxing Family Vacation

8/10 Good

"We booked this for a quiet getaway. Everything was exactly as described and more. The kitchen was fully stocked with everything we needed except the groceries. We loved the dock, my husband even caught a few catfish. We only stayed 3 nights but will definitely be coming back for a longer stay."

More cheap accommodation in East Prairie

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

AU$104

9 Sept - 10 Sept

includes taxes & fees

7.2/10 Good! (1,014 reviews)

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

AU$133

30 Aug - 31 Aug

includes taxes & fees

9.2/10 Wonderful! (422 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

AU$154

16 Aug - 17 Aug

includes taxes & fees

8.4/10 Very good! (1,005 reviews)

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

AU$155

23 Aug - 24 Aug

includes taxes & fees

8.8/10 Excellent! (494 reviews)

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

AU$158

23 Aug - 24 Aug

includes taxes & fees

Holiday Inn Express & Suites Union City by IHG

810 BREAM BOULEVARD Union City TN

AU$185

23 Aug - 24 Aug

includes taxes & fees

Frequently asked questions

What is the best area to stay in East Prairie?

The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.For travellers looking for a straightforward and practical base, staying near Main Street is ideal.

When is the best time to go to East Prairie?

The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.

How can I save on a hotel booking in East Prairie with Expedia?

One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on East Prairie hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

How much is the nightly rate for a hotel in East Prairie?

Prices for hotels in East Prairie often vary, but you can find a great deal from AU$88 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Search East Prairie hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

2. Hampton Inn Sikeston

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

4. Best Western Plus Sikeston I-55

5. Fairfield Inn & Suites by Marriott Sikeston

6. Comfort Inn & Suites Sikeston I-55

7. The Riverstone Hotel Charleston-Sikeston

8. TownePlace Suites by Marriott Sikeston

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. Super 8 by Wyndham Charleston/Sikeston East MO

11. Days Inn and Suites by Wyndham Sikeston

12. Super 8 By Wyndham Marston

13. Eagle Inn Charleston

14. Country Yard Inn and Suite

15. Quality Inn Cairo I-57

16. Sleep Inn at Discovery Park of America

17. Travel Inn Marston I-55 by Hotel O

18. Country Hearth Inn & Suites Union City

19. Quality Inn Union City US 51

20. Super 8 by Wyndham Sikeston/Miner Area

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Sleep Inn at Discovery Park of America

Super 8 by Wyndham Charleston/Sikeston East MO

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Quality Inn Union City US 51

Best Western Plus Sikeston I-55

Holiday Inn Express & Suites Sikeston Southwest by IHG

Days Inn and Suites by Wyndham Sikeston

Comfort Inn & Suites Sikeston I-55

Duck Hunting, Fishing or Relaxing Family Vacation

More cheap accommodation in East Prairie

Days Inn and Suites by Wyndham Sikeston

Sleep Inn at Discovery Park of America

Best Western Plus Sikeston I-55

Holiday Inn Express & Suites Sikeston Southwest by IHG

Hampton Inn Sikeston

Holiday Inn Express & Suites Union City by IHG

Frequently asked questions

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