Search East Prairie hotels

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1005)
"the hotel was very clean"
United States
Eric
Travelling with family
The price is AU$156
includes taxes & fees
23 Dec - 24 Dec
Drury Inn & Suites Sikeston, MO

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1004)
"The bed was clean and comfortable"
United States
Whitney
Travelling with family
The price is AU$130
includes taxes & fees
23 Dec - 24 Dec
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (719)
"Otherwise, the room and property were very clean, the staff friendly."
United States
Les
Travelling solo
The price is AU$95
includes taxes & fees
23 Dec - 24 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (445)
"the king bed was great"
United States
Hailey
Travelling solo
The price is AU$168
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Sikeston

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (318)
"Loved the shower with glass doors."
United States
Terra
Travelling with partner
The price is AU$145
includes taxes & fees
7 Jan - 8 Jan 2026
Sleep Inn at Discovery Park of America

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
"I really liked the hotel, it was also walking distance to our destination."
United States
Devonda
Travelling for leisure
The price is AU$165
includes taxes & fees
15 Jan - 16 Jan 2026
Holiday Inn Express & Suites Union City by IHG

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
"Great hotel, great staff"
United States
Dmitry
The price is AU$99
includes taxes & fees
21 Dec - 22 Dec
Super 8 By Wyndham Marston

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (486)
"Location is next to a very good italian restaurant (Mousto's)."
United States
Richard
Travelling for leisure
The price is AU$120
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Union City US 51

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Clean hotel with a wonderful, hot breakfast."
United States
Melanie
Travelling with family
The price is AU$130
includes taxes & fees
23 Dec - 24 Dec
Pear Tree Inn Sikeston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (726)
"The room itself was pretty nice even though a bit outdated it was worth the price paid."
United States
Carol
Travelling for leisure
New Orleans Inn Portageville

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Clean rooms, helpful and polite staff"
United States
Jennifer
Travelling with partner
The price is AU$129
includes taxes & fees
26 Dec - 27 Dec
Country Hearth Inn & Suites Union City

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
"Very clean and comfortable room."
United States
Roxanne
Travelling solo
The price is AU$172
includes taxes & fees
25 Dec - 26 Dec
Fairfield Inn & Suites by Marriott Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
"Great price and excellent room."
United States
David
Travelling for business
The price is AU$104
includes taxes & fees
23 Dec - 24 Dec
Super 8 by Wyndham Charleston/Sikeston East MO

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (164)
"Very clean nice quiet rooms"
United States
april
Travelling with family
The price is AU$171
includes taxes & fees
23 Dec - 24 Dec
Hampton Inn Union City

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
"The only good thing about the stay is the beds were comfortable"
United States
NICOLE
Travelling with friends
The price is AU$122
includes taxes & fees
10 Jan - 11 Jan 2026
Quality Inn Cairo I-57

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Friendly staff, clean room, easy in and out."
United States
Christopher
The price is AU$159
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (282)
"hotel was fine clean and convient"
United States
Denise
Travelling solo
The price is AU$145
includes taxes & fees
31 Dec - 1 Jan 2026
Comfort Inn & Suites Sikeston I-55

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is AU$201
includes taxes & fees
25 Dec - 26 Dec
TownePlace Suites by Marriott Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1004)
"The beds were clean and comfortable so that is a plus."
United States
KIM S
Travelling with partner
The price is AU$108
includes taxes & fees
21 Dec - 22 Dec
Days Inn and Suites by Wyndham Sikeston

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
"Perfect, staff was very helpful."
United States
Marcos
The price is AU$168
includes taxes & fees
21 Dec - 22 Dec
MainStay Suites Union City, TN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

More cheap accommodation in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Hampton Inn Sikeston, located 12.1 mi (19.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Drury Inn & Suites Sikeston, MO and Sleep Inn at Discovery Park of America. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and New Madrid Historical Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

Explore a world of travel with Expedia